2 edition of anticonvulsant profiles of two calcium channel antagonists in animal models of epilepsy. found in the catalog.
anticonvulsant profiles of two calcium channel antagonists in animal models of epilepsy.
Manchester thesis (Ph.D.), Faculty of Medicine.
|Contributions||University of Manchester. Faculty of Medicine.|
|The Physical Object|
|Number of Pages||294|
Preventive migraine treatments include beta-blockers, antidepressants, calcium channel antagonists, 5-hydroxytryptamine antagonists, anticonvulsants, and NSAIDs. The two drugs, known as Z and Z, were designed to block T-type calcium channels, which are involved in pain as well as epilepsy, according to the authors of a Feb. 15 paper in Science Translational Medicine. The two drugs “attenuated burst firing of thalamic reticular nucleus neurons” in a rat model of absence seizures, the authors.
Antiepileptic drugs (AEDs) provide satisfactory control of seizures for most patients with epilepsy. The T-type calcium channel family (Ca v 3) W. Animal models of epilepsy for the Cited by: The use of cannabis products in the treatment of epilepsy has long been of interest to researchers and clinicians alike; however, until recently very little published data were available to support its use. This article summarizes the available scientific data of pharmacology from human and animal studies on the major cannabinoids which have been of interest in the treatment of epilepsy Cited by:
This study was aimed at examining the effects of two frequently used Ca2+ antagonists, nitrendipine and verapamil, on withdrawal after cessation of long-term treatment with the anticonvulsant drug. Classic calcium channel blockers such as verapamil and nifedipine act as anticonvulsants (Czuczwar et al., a, b; Kamal et al., ; Meyer et al., ) and heighten the anesthetic effects of barbiturates and benzodiazepines (Dolin and Little, ; Dolin et al.,
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The anticonvulsant activity of calcium channel antagonists, was studied after intrapcritoneal or oral administration in genetically epilepsy prone rats (GEPR). Flunarizine, dihydropyridines and HAadministered intraperitoneally, were the most potent by: In animal models of epilepsy, calcium entry blockers have shown anticonvulsant properties.
We studied the antiepileptic effects of nimodipine and two novel dihydropyridines, a calcium antagonist (PCA ) and a calcium agonist (PCA ), on pentylenetetrazole seizure and maximal electroshock seizure (MES) in by: 2. The anticonvulsant effects were evaluated on seizures evoked by means of auditory stimulation ( dB) in animals placed singly under a perspex dome.
Flunarizine and dihydropyridine derivatives, belonging to class I of calcium entry blockers, administered intraperitoneally, were the Cited by: This study describes, for the first time, the enhancing effect of calcium channel blockers on both the anticonvulsant and antinociceptive activities of VPA in a PTZ animal convulsion model.
Seizures can arise when there is a disruption of mechanisms that normally Cited by: Smith SE, Dürmüller N, Meldrum BS () The non-N-methyl-D-aspartate receptor antagonists, GYKI and NBQX are anticonvulsant in two animal models of reflex epilepsy. Eur J Pharmacol – PubMed Google Scholar.
Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitredipine and nimodipine Author links open overlay panel Simon J. Dolin 1 Anthony B. Hunter 2 Michael J. Halsey 2 Hilary J Cited by: These hypotheses, however, are challenged by different findings, e.g., the antipsychotic effects of drugs such as lithium salts, anticonvulsants, and calcium (Ca 2+) channel blockers, which differ from “classical” neuroleptics and antidepressants in their chemical structure and : M.
Dose, H. Emrich. Abstract. Anticonvulsants are a class of neuronally active medications first licensed to treat epilepsy and neuropathic pain. Among these, the gabapentinoids, the GABA-derivatives gabapentin and pregabalin, have been used with success to treat post-herpetic neuralgia, a chronic neuropathic condition characterized by pain, itch and dysesthesia.
AMPA receptor antagonists, which are anticonvulsant in a broad range of rodent animal models and also in photosensitive baboon, may have greater potential clinical utility than do the NMDA antagonists. 25, – In fact, they may be active in in vitro epilepsy models even when NMDA receptor antagonists are not.
AMPA receptor Cited by: These same mood stabilizing effects are seen with some anticonvulsants which also act as calcium antagonists. Therefore, it is reasonable to assume that part of the reason why some anticonvulsants stabilize mood is because of their ability to work on calcium, calcium channel blockers, and inositol, as seen in Lithium and calcium channel blockers.
In this study the anticonvulsant properties of two novel dihydropyridine derivatives was observed and our results are in consistence with other studies (6,9–12). The antiepileptic effect of dihydropyridines and other calcium channel blockers may be related to the inhibition of calcium.
The influx/efflux of calcium (Ca2+) ions through channels in cellular membranes plays a pivotal role in many physiological and physiopathological processes.
Among these are those involved in the physiopathology of epileptic seizures. Hence, the control of permeability of ions through these channels is considered a strategy for the development of anticonvulsant by: 3.
ABSTRACT:Epilepsy is a neurological disorder characterized by excessive electrical discharge in brain, which causes therapeutic strategy in countering epilepsy involves reducing neuronal excitability through different mechanistic pathway.
Most therapeutics currently used in the treatment of epilepsy is either directed towards blocking voltage-gated sodium and calcium channels or. This review describes new anticonvulsant agents representing various.
effects in the same animal model. It was observed that channel blockers, phenytoin and lamotrigine, provided Although drugs targeting the cannabinoid system (e.g., CB1 receptor agonists) display anticonvulsant efficacy in adult animal models of seizures/epilepsy, they remain unexplored in developing animal models.
However, cannabinoid system functions emerge early in development, providing a rationale for targeting this system in by: 8. found to be depressed by calcium ion channel block-ers [23, 46]. Accordingly, we aimed in the current study to evaluate the modulatory effects of three calcium channel blockers; diltiazem, nifedipine, or verapamil, on the anticonvulsant and antinociceptive activities of VPA in pentylenetetrazole (PTZ)-kindled mice.
Materials and Methods. Background: Epilepsy is one common neurological disorder requiring newer targets and newer drugs for its efficient the recent days brain renin angiotensin system has gained immense importance because of its involvement in seizure regulation.
Objective: To evaluate and compare antiepileptic activity of different doses olmesartan and telmisartan on MES and PTZ induced seizure by: 3.
The aim of this study was to assess the effect of three calcium channel antagonists (amlodipine, diltiazem and verapamil) on the anticonvulsant action of lamotrigine (a second generation.
Introduction. Epilepsy affects approximately two million Americans and 65 million people worldwide ().Among those with epilepsy, 22–30% have drug-resistant epilepsy (DRE) (1, 2).DRE causes cognitive and mood impairment, injuries, and increased risk of death including sudden death in epilepsy (SUDEP) (1–3).Antiepileptic drugs (AEDs) are the primary medical treatment for by: 6.
The aim of the present experiments was to examine anticonvulsant activity of new pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione derivatives in animal models of epilepsy. In addition, the possible collateral antinociceptive activity was by:.
Rufinamide (Inovelon/Banzel; Novartis/Eisai) is a triazole derivative that was found to have a broad-spectrum anticonvulsant profile in animal seizure and epilepsy models Cited by: Moreover, nimodipine has a different profile of anticonvulsant effects in animal models and, in contrast to verapamil, blocks cocaine-induced hyperactivity and its associated dopamine overflow Cited by: Summary: Pregabalin is a potent ligand for the alpha‐2‐delta subunit of voltage‐gated calcium channels in the central nervous system that exhibits potent anticonvulsant, analgesic, and anxiolytic activity in a range of animal models.
In addition, pregabalin has been shown to be a highly effective adjunctive therapy for partial seizures in clinical by: